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Discovery Chemistry

Our Organic chemists work in conjunction with medicinal and computational chemists to design and synthesize potent drug-like compounds

Medicinal Chemistry CRO Services

  • Scaffold hopping
  • Hit-to lead discovery
  • Lead compound optimization
  • Structure activity relationship study
  • Improve selectivity profile of small molecule compounds
  • Improve in vivo efficacy of compounds
  • Optimize PK profile of compounds
  • Pro-drug synthesis
  • Backup compound planning and synthesis
  • Novel Route Scouting
  • Focused library design
  • Integrated Solutions

Key Equipment

  • Glove box
  • Biotage Initiator microwave synthesizer
  • Biotage Flash Chromatograph System
  • Heidolph Rotary evaporators
  • Thermo Recirculating Chillers
  • IKA Hot plate and stirrers
  • Distillation assembly
  • Genevac HT-4x. Evaporator
  • Labconco 77500 Freeze Dryer
  • Thermo Savant Refrigerated Vapor Trap
  • Nitrogen, Argon and Hydrogen gas
  • Hot Air Oven and Vacuum Oven
  • Barnstead stirrers
  • Grace Reveleris X2 Flash Chromatography systems

Computational chemists at Redox design drug-like compounds (obeying Lipinski’s and other rules) in conjunction with clients, to expedite hit-to-lead and lead-to-drug discovery process. Redox Scientific provides following services using advanced molecular modelling software suites:

  • Structure based drug design and flexible docking
  • Homology modeling
  • Virtual library screening
  • Molecular dynamics
  • Ligand based drug design (QSAR)
  • 3D-Pharmacophore hopping
  • Drug Design and Drug Development

Redox Scientific expertise in providing following custom synthesis services.

  • Compounds for SAR or Animal studies
  • Building blocks
  • Compound Libraries
  • Deuterated or labelled compounds
  • Chemical Biology Tools
  • Catalysts
  • Ultrapure compounds
  • Low trace metal compounds
  • Moisture sensitive compounds
  • Custom Development and Manufacturing

Research team at Redox provides following impurity profiling services for API, intermediates, or drug products:

  • Isolate process related impurities and degradation products
  • Identify and characterize each impurity using modern analytical techniques
  • Synthesize identified impurities for further investigation and reference standards
  • Good laboratory practice

Key Equipment:

  • Agilent LCMS: 1100 Series LC & G1946C MS
  • Bruker HCT ULTRA Mass Spectrometer (ESI)
  • Waters HPLC 2695 Alliance
  • Thermo trace ultra GC
  • Pharmacia Biotech Ultrospec 2000
  • Waters Micromass ZQ Mass Spectrometer
  • Thermo scientific Conductivity Tester
  • Beckman Coulter pH/Temp/mV Meter

Contact us to learn more