Our Organic chemists work in conjunction with medicinal and computational chemists to design and synthesize potent drug-like compounds
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Discovery Chemistry
Medicinal Chemistry CRO Services
- Scaffold hopping
- Hit-to lead discovery
- Lead compound optimization
- Structure activity relationship study
- Improve selectivity profile of small molecule compounds
- Improve in vivo efficacy of compounds
- Optimize PK profile of compounds
- Pro-drug synthesis
- Backup compound planning and synthesis
- Novel Route Scouting
- Focused library design
- Integrated Solutions
Key Equipment
- Glove box
- Biotage Initiator microwave synthesizer
- Biotage Flash Chromatograph System
- Heidolph Rotary evaporators
- Thermo Recirculating Chillers
- IKA Hot plate and stirrers
- Distillation assembly
- Genevac HT-4x. Evaporator
- Labconco 77500 Freeze Dryer
- Thermo Savant Refrigerated Vapor Trap
- Nitrogen, Argon and Hydrogen gas
- Hot Air Oven and Vacuum Oven
- Barnstead stirrers
- Grace Reveleris X2 Flash Chromatography systems
Computational chemists at Redox design drug-like compounds (obeying Lipinski’s and other rules) in conjunction with clients, to expedite hit-to-lead and lead-to-drug discovery process. Redox Scientific provides following services using advanced molecular modelling software suites:
- Structure based drug design and flexible docking
- Homology modeling
- Virtual library screening
- Molecular dynamics
- Ligand based drug design (QSAR)
- 3D-Pharmacophore hopping
- Drug Design and Drug Development
Redox Scientific expertise in providing following custom synthesis services.
- Compounds for SAR or Animal studies
- Building blocks
- Compound Libraries
- Deuterated or labelled compounds
- Chemical Biology Tools
- Catalysts
- Ultrapure compounds
- Low trace metal compounds
- Moisture sensitive compounds
- Custom Development and Manufacturing
Research team at Redox provides following impurity profiling services for API, intermediates, or drug products:
- Isolate process related impurities and degradation products
- Identify and characterize each impurity using modern analytical techniques
- Synthesize identified impurities for further investigation and reference standards
- Good laboratory practice
Key Equipment:
- Agilent LCMS: 1100 Series LC & G1946C MS
- Bruker HCT ULTRA Mass Spectrometer (ESI)
- Waters HPLC 2695 Alliance
- Thermo trace ultra GC
- Pharmacia Biotech Ultrospec 2000
- Waters Micromass ZQ Mass Spectrometer
- Thermo scientific Conductivity Tester
- Beckman Coulter pH/Temp/mV Meter
